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- W2358514003 abstract "OBJECTIVE To develop a sensitive and specific LC-MS-MS method for the determination of caudatin in rat plasma.METHODS The analyte was extracted from plasma with acetoacetate with norethisterone as internal standard,then separated on a prepacked C18-column.The mobile phase consisted of acetonitrile and water(70∶30),at a flow rate of 1.0 mL·min-1.A mass spectrometer was used as detector and operated in the positive ion mode.In multiple reaction monitoring(MRM)mode,the ion combinations of m/z 514.1→385.4[M+Na+] and m/z 299.7→108.9 [M+H+] were used to qualify caudatin and IS,respectively.RESULTS Chromatograms showed no endogenous interfering peaks.Each analysis was completed within 5 min.The caudatin calibration was linear in the concentration range of 2.5～1 000 μg·L-1.The intra-batch and inter-batch RSDs were less than 15%.The recovery of the extraction was more than 80%.CONCLUSION The method is proved to be suitable for caudatin pharmacokinetics." @default.
- W2358514003 created "2016-06-24" @default.
- W2358514003 creator A5090316356 @default.
- W2358514003 date "2008-01-01" @default.
- W2358514003 modified "2023-09-23" @default.
- W2358514003 title "Study on Determination of Caudatin in Rat Plasma by LC-MS-MS" @default.
- W2358514003 hasPublicationYear "2008" @default.
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