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- W2358524519 abstract "Objective To analyze the mutation of NF2 gene (exon 2,4,6 and 13) in schwannomas. Methods The NF2 gene mutation in 36 schwannomas were observed by PCR-SSCP and DNA sequence. The proliferative index of schwannoma was detected by immunohistochemistry. Results We found 13 mutations in 36 schwannomas, including 6 deletion or insertion resulting in a frameshift, 2 nonsense mutations, 2 missense mutations, and 3 alterations affecting acceptor or donor of splicing sites in E4,E6,E13. The proliferative index of schwannomas with mutation were significantly higher than those without mutation(P0.05). Conclusion NF2 gene mutation is the frequent event in the tumorigenesis of schwannomas, and there is some correlation between the mutation and clinical behavior(tumor proliferation)." @default.
- W2358524519 created "2016-06-24" @default.
- W2358524519 creator A5083727290 @default.
- W2358524519 date "2002-01-01" @default.
- W2358524519 modified "2023-09-24" @default.
- W2358524519 title "THE ANALYSIS OF NF2 GENE MUTATION IN SPORADIC SCHWANNOMAS" @default.
- W2358524519 hasPublicationYear "2002" @default.
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