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- W2358530905 abstract "Objective To analyze the clinical features of renal transplantation in the aged and the influence of im-munosuppressant on transplantation result in the elderly recipients. Methods From 1990 to 2001, renal transplantation for 1 390 cases was performed in Xinqiao Hospital and 152 of them were elderly recipients. The clinical data of the aged over 60 after renal transplantation were retrospectively analysed. The aged recipients were divided into group A and group B. Ciclosporin (CsA), azathioprine (Aza) and prednisone were given to the group A. In the group B, in addition to CsA, mycophenolate mofetil (MMF), prednisone and OKT3 were given to 51 aged recipients and dacliximab (Daclizumab, Ze-napax) or basiliximab (Smulect) was injected into the other 46 aged recipients within 2 hours prior to transplantation and on 14th day after-transplantation for prophylaxis of acute rejection. The group B was compared with the group A in complications, the rate of acute rejection and the one-year survival rate of patients/allografts. Results The rate of complication of cardio- and cerebro-vascular disease and infection in the aged recipients were higher than those in the non-elderly recipients. In groups A and B, the rate of postoperative complications was 83.6% and 39.2% , the rate of acute rejection was 21.82% and5.73%, and one-year survival rate of patients/allografts was 81.8%/78.2% and 92. 8%/90.8% , respectively. Conclusions The cardio-and cerebro-vascular disease and infection complications were the main risk factors affecting the outcome of renal transplantation in the senile recipients. The quadruple immunosuppressant regimens could reduce postoperative complications and acute rejection, and improve one-year survival rate of patients/allografts in the aged recipients." @default.
- W2358530905 created "2016-06-24" @default.
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- W2358530905 date "2003-01-01" @default.
- W2358530905 modified "2023-09-23" @default.
- W2358530905 title "Clinical features of renal transplantation in the elderly patients" @default.
- W2358530905 hasPublicationYear "2003" @default.
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