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- W2358536412 abstract "Objective: The effect of noradrenaline (NA) at various concentrations and different action times as well as adrenergic receptors on T lymphocyte function in vitro was investigated in order to know the regulatory role and mechanism of neurotransmitter NA on cellular immunity. Methods: Rat splenocytes were stimulated by concanavalin A (Con A) and incubated for 72 hours. NA at 10 -10 to 10 -5 mol/L concentrations or different time after Con A stimulation was added to splenocyte suspension, or adrenergic receptor antagonist was added to splenocyte suspension containing NA. MTT colorimetric assay was used to determine the conversion of rat splenocytes. Results: NA, in the range of 10 -8 to 10 -5 mol/L, significantly attenuated the conversion of T lymphocytes and the strongest inhibition emerged at 10 -7 mol/L NA. T lymphocyte conversion was still diminished either when NA acted with T cells having stimulated by Con A for an hour or when NA was washed off after one-hour incubation with T cells. However, the T cell conversion did not change when NA acted with T cells having incubated with Con A for 6 hours. The NA suppression of T cell conversion could be blocked either by α-adrenergic antagonist phentolamine or by β-adrenergic antagonist propranolol. Conclusion: It is suggested that NA exert a concentration-independent inhibitory effect on the T lymphocyte function in vitro, which may be related to the early events involved in the initiation of the T cell conversion and be mediated by either alpha- or beta- adrenergic receptors." @default.
- W2358536412 created "2016-06-24" @default.
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- W2358536412 date "2000-01-01" @default.
- W2358536412 modified "2023-09-23" @default.
- W2358536412 title "EFFECT OF NORADRENALINE ON T LYMPHOCYTE FUNCTION IN VITRO" @default.
- W2358536412 hasPublicationYear "2000" @default.
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