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• W2358552004 abstract "Arthritis pain affects millions of people worldwide yet we still have only a limited understanding of what makes our joints ache. This review examines the sensory innervation of diarthroidal joints and discusses the neurophysiological processes that lead to the generation of painful sensation. During inflammation, joint nerves become sensitized to mechanical stimuli through the actions of neuropeptides, eicosanoids, proteinase-activated receptors and ion channel ligands. The contribution of immunocytes to arthritis pain is also reviewed. Finally, the existence of an endogenous analgesic system in joints is considered and the reasons for its inability to control pain are postulated." @default.
• W2358552004 created "2016-06-24" @default.
• W2358552004 creator A5004167898 @default.
• W2358552004 date "2006-01-01" @default.
• W2358552004 modified "2023-09-27" @default.
• W2358552004 title "Review Arthritis and pain: Neurogenic origin of joint pain" @default.
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