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- W2358554089 abstract "OBJECTIVE To find the inflammation biomarkers induced by coke oven emissions( COE),we investigated the changes of T helper 17( Th17) cytokines in human bronchial epithelial( 16HBE) cells. METHODS 16HBE cells were exposed to organic extracts of COE collected from coking plant at the concentrations of 5,10 and 20 mg·L-1for 24 h or 5 d to establish short-term and longterm cell models,respectively. Cell viability was measured by MTT assay and inflammatory damage was assessed by lactate dehydrogenase assay( LDH). The cytokines in culture supernatant samples was detected by commercial human Th17 cytokine panel kit. RESULTS COE Can induce inflammation in COE 20 mg·L-1group and no expression on IL-17 F and IL-1 β. The concentration of IL-10 was 1. 25 ± 0. 54,1. 39 ± 0. 13 and( 1. 90 ± 0. 73) pg·mL-1in COE 5,10 and 20 mg·L-1group showing good concentration-effect relationship( r = 0. 98,P 0. 05). IL-23 expression was found only higher at 10 and 20 mg·L-1and the concentrations were 3. 38 ± 3. 90 and( 1. 74 ± 2. 00) pg·mL-1,respectively. In 16HBE cells treated by COE for 5 d,elevated expression of IL-17A was found in COE 5 and 10 mg·L-1 group,and there was statistically sigificant difference between COE 10 mg·L-1and DMSO group( P 0.05). Elevated concentration of IL-17F of 10.2 ±11.78 and( 6.79 ±7.84) pg·mL-1was found in COE 5 and 10 mg·L-1group. The concentration of IL-10 was 1. 71 ± 0. 02,1. 49 ± 0. 25 and( 2. 82 ± 0. 33) pg·mL-1in COE 5,10 and 20 mg·L-1group,respectively. We found increased IL-1β expression with concentration of 2. 72 ± 0. 62,2. 25 ± 0. 33 and( 0. 93 ± 0. 21) pg·mL-1in COE 5,10 and 20 mg·L-1group with negative dose-response relationship. We also found more elevated TNF-α levels in the 5 d than in the 24 h model with no COE specific relationship. CONCLUSION COE induces expression changes of Th17 cytokines profile in 16HBE cells,including IL-23 and IL-1β for early and longterm inflammation,respectively. IL-10 may be a candidate marker for population study on COE induced inflammatory injury." @default.
- W2358554089 created "2016-06-24" @default.
- W2358554089 creator A5036631276 @default.
- W2358554089 date "2014-01-01" @default.
- W2358554089 modified "2023-09-26" @default.
- W2358554089 title "Changes of Th17 cytokine in human bronchial epithelial cells induced by coke oven emission" @default.
- W2358554089 hasPublicationYear "2014" @default.
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