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- W2358564002 endingPage "365" @default.
- W2358564002 startingPage "359" @default.
- W2358564002 abstract "In eukaryotic transcription initiation, a large multi-subunit pre-initiation complex (PIC) that assembles at the core promoter is required for the opening of the duplex DNA and identification of the start site for transcription by RNA polymerase II. Here we use cryo-electron microscropy (cryo-EM) to determine near-atomic resolution structures of the human PIC in a closed state (engaged with duplex DNA), an open state (engaged with a transcription bubble), and an initially transcribing complex (containing six base pairs of DNA-RNA hybrid). Our studies provide structures for previously uncharacterized components of the PIC, such as TFIIE and TFIIH, and segments of TFIIA, TFIIB and TFIIF. Comparison of the different structures reveals the sequential conformational changes that accompany the transition from each state to the next throughout the transcription initiation process. This analysis illustrates the key role of TFIIB in transcription bubble stabilization and provides strong structural support for a translocase activity of XPB." @default.
- W2358564002 created "2016-06-24" @default.
- W2358564002 creator A5006718110 @default.
- W2358564002 creator A5024544328 @default.
- W2358564002 creator A5034946559 @default.
- W2358564002 creator A5036415725 @default.
- W2358564002 creator A5077972143 @default.
- W2358564002 creator A5079549927 @default.
- W2358564002 creator A5082330841 @default.
- W2358564002 date "2016-05-11" @default.
- W2358564002 modified "2023-10-01" @default.
- W2358564002 title "Near-atomic resolution visualization of human transcription promoter opening" @default.
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