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- W2358592162 abstract "Objective To investigate the effects of insulin-like growth factor-1(IGF-1),IGF-2,IGF binding proteins-3(IGFBP-3) in maternal serum on fetal growth.Methods Sixty-six cases of primiparas with prenatal check-up and delivery of normal birth weight infant from Jan.,2010 to May.,2011 were selected in this study.Maternal serum at 16-18,26-28 and 37-40 gestational weeks were obtained for measuring IGF-1、IGF-2、IGFBP-3 by enzyme-linked immunosorbent assay(ELISA).Results There was marked increase in maternal serum IGF-1 during pregnancy,of which serum IGF-1 at 37-40 gestational weeks was significantly higher than the level at 26-28 weeks,and 26-28 weeks significantly higher than 16-18 weeks(P0.001).There was no significant change in maternal serum IGF-2 at early,mid and full term stage of pregnancy(P0.05).Maternal serum IGFBF-3 at 37-40 gestational weeks was significantly higher than the level at 26-28 and 16-18 weeks(P0.05),but no difference between 26-28 weeks and 16-18 weeks(P0.05).No significant correlation between maternal serum IGF-1,IGF-2,IGFBP-3 and birth weight of newborn infants was observed at different gestational stages during pregnancy.Conclusions IGF-1 and IGFBP-3 might be related to fetal growth,of which IGF-1 could be a clinical biomarker for evaluation of normal fetal growth at different gestational stages,while IGFBP-3 would reflect more normal fetal growth at mid and late gestational stages." @default.
- W2358592162 created "2016-06-24" @default.
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- W2358592162 date "2012-01-01" @default.
- W2358592162 modified "2023-09-23" @default.
- W2358592162 title "The correlation between maternal serum IGF-1,IGF-2,IGFBP-3 levels and normal fetal growth" @default.
- W2358592162 hasPublicationYear "2012" @default.
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