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- W2358601345 abstract "Objective: To investigate the expression of signal transducers and activators of transcription 3(STAT3) in the human oral squamous cell carcinoma and to evaluate the relationship between protein level and clinicopathological parameters.Methods: The immunohistochemistry SABC was used to detect the expression of STAT3 in human oral squamous cell carcinoma and precancerous lesion.The automatic image analyser was used to analyse the gray scale of the STAT3.Result: STAT3 protein level significantly increased in squamous cell carcinoma tissue compared with precancerous lesion(P0.01).There were statistical differences in the average gray scale between different differentiated cancers of STAT3 protein(P0.05).The expression of STAT3 was higher in poor-differentiated cancers than in well-differentiated cancers.Protein level of STAT3 in the stage Ⅲ and stage Ⅳ carcinomas was higher than that in stage Ⅰ and stage Ⅱ carcinomas(P0.01).Conclusion: Overexpression of STAT3 may play an important role in the tumorgenesis,development and the clinical stage of the human oral squamous cell carcinoma." @default.
- W2358601345 created "2016-06-24" @default.
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- W2358601345 date "2008-01-01" @default.
- W2358601345 modified "2023-09-22" @default.
- W2358601345 title "Expression and Significance of STAT3 in Human Oral Squamous Cell Carcinoma" @default.
- W2358601345 hasPublicationYear "2008" @default.
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