Matches in SemOpenAlex for { <https://semopenalex.org/work/W2358622083> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2358622083 endingPage "51" @default.
- W2358622083 startingPage "246" @default.
- W2358622083 abstract "The purpose of the investigation was to determine the effects of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (AA) on the isolated rabbit aortic strips. The results showed that (1) the rabbit aortic strips with intact endothelium contracted in a dose-dependent manner to exogenous AA between the concentrations of 2.5 x 10(-6) mol/L and 4 x 10(-5) mol/L. EPA did not affect the tension of the relaxing strips, but inhibited the contractile response to AA (2 x 10(-5) mol/L), IC50 = 9.94 x 10(-6) mol/L. DHA showed no significant effect on the contractile response to AA. (2) In the endothelium-damaged rabbit aorta, the contraction of strips to AA was drastically diminished. The inhibitory effect of EPA on the contraction to AA was almost vanished. (3) The contraction of rabbit aortic strips to AA was shown to be abolished by indomethacin (1.5 x 10(-5) mol/L), a cyclooxygenase inhibitor. (4) Radioimmunoassay showed that exogenous AA increased the tissue levels of 6-keto-PGF1 alpha, TXB2 and their ratio. Lower dose of EPA (1.5 x 10(-6) or 1.5 x 10(-5) mol/L) did not affect the tissue levels of 6-keto-PGF1 alpha and TXB2. However, EPA at higher concentrations decreased the metabolites of AA significantly. These findings suggest that exogenous AA induces the contraction of rabbit aortic strips in vitro, which is related to the endothelial cells and mediated by the metabolites(s) of cyclooxygenase, likely endothelium-derived contracting factor (EDCF).(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2358622083 created "2016-06-24" @default.
- W2358622083 creator A5010950466 @default.
- W2358622083 creator A5018752976 @default.
- W2358622083 creator A5076840362 @default.
- W2358622083 date "1992-01-01" @default.
- W2358622083 modified "2023-10-03" @default.
- W2358622083 title "[Effects of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid on tension of rabbit aortic strips]." @default.
- W2358622083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1442036" @default.
- W2358622083 hasPublicationYear "1992" @default.
- W2358622083 type Work @default.
- W2358622083 sameAs 2358622083 @default.
- W2358622083 citedByCount "0" @default.
- W2358622083 crossrefType "journal-article" @default.
- W2358622083 hasAuthorship W2358622083A5010950466 @default.
- W2358622083 hasAuthorship W2358622083A5018752976 @default.
- W2358622083 hasAuthorship W2358622083A5076840362 @default.
- W2358622083 hasConcept C126322002 @default.
- W2358622083 hasConcept C134018914 @default.
- W2358622083 hasConcept C163415756 @default.
- W2358622083 hasConcept C181199279 @default.
- W2358622083 hasConcept C185592680 @default.
- W2358622083 hasConcept C19038510 @default.
- W2358622083 hasConcept C2776091944 @default.
- W2358622083 hasConcept C2776992346 @default.
- W2358622083 hasConcept C2777171753 @default.
- W2358622083 hasConcept C2778078955 @default.
- W2358622083 hasConcept C2779689624 @default.
- W2358622083 hasConcept C2779980429 @default.
- W2358622083 hasConcept C543025807 @default.
- W2358622083 hasConcept C55493867 @default.
- W2358622083 hasConcept C71924100 @default.
- W2358622083 hasConcept C86803240 @default.
- W2358622083 hasConceptScore W2358622083C126322002 @default.
- W2358622083 hasConceptScore W2358622083C134018914 @default.
- W2358622083 hasConceptScore W2358622083C163415756 @default.
- W2358622083 hasConceptScore W2358622083C181199279 @default.
- W2358622083 hasConceptScore W2358622083C185592680 @default.
- W2358622083 hasConceptScore W2358622083C19038510 @default.
- W2358622083 hasConceptScore W2358622083C2776091944 @default.
- W2358622083 hasConceptScore W2358622083C2776992346 @default.
- W2358622083 hasConceptScore W2358622083C2777171753 @default.
- W2358622083 hasConceptScore W2358622083C2778078955 @default.
- W2358622083 hasConceptScore W2358622083C2779689624 @default.
- W2358622083 hasConceptScore W2358622083C2779980429 @default.
- W2358622083 hasConceptScore W2358622083C543025807 @default.
- W2358622083 hasConceptScore W2358622083C55493867 @default.
- W2358622083 hasConceptScore W2358622083C71924100 @default.
- W2358622083 hasConceptScore W2358622083C86803240 @default.
- W2358622083 hasIssue "4" @default.
- W2358622083 hasLocation W23586220831 @default.
- W2358622083 hasOpenAccess W2358622083 @default.
- W2358622083 hasPrimaryLocation W23586220831 @default.
- W2358622083 hasRelatedWork W1995898587 @default.
- W2358622083 hasRelatedWork W2009454127 @default.
- W2358622083 hasRelatedWork W2027450319 @default.
- W2358622083 hasRelatedWork W2050387849 @default.
- W2358622083 hasRelatedWork W2054234087 @default.
- W2358622083 hasRelatedWork W2085207157 @default.
- W2358622083 hasRelatedWork W2098708274 @default.
- W2358622083 hasRelatedWork W2246272397 @default.
- W2358622083 hasRelatedWork W2358622083 @default.
- W2358622083 hasRelatedWork W3143028553 @default.
- W2358622083 hasVolume "27" @default.
- W2358622083 isParatext "false" @default.
- W2358622083 isRetracted "false" @default.
- W2358622083 magId "2358622083" @default.
- W2358622083 workType "article" @default.