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- W2358622168 abstract "Objective To investigate the effect of Gypenosides(GP)on the injury induced by cerebral ischemia reperfusion in rats and its protective mechanisms.Methods In this study,we set up cerebral ischemia reperfusion model in rats by blocking middle cerebral artery.Rats were randomly divided into six groups:sham group,model group,Shuxuening group and GP-treated groups(100、30和10mg·kg-1).To observe the neurologic deficit score,the level of SOD,MDA,NO,infarction area in the brain tissue and HE Histopathological change.Immunohistochemistry method was used to measure Bcl-2 and Bax expressions.Results Compared with model group,GP groups could significantly reduce the neurologic deficit score,increase the SOD activity,decrease the MDA contents and infarction area of the brain tissue.The Immunohistochemistry results showed that GP could significantly increase the expression of Bcl-2 and reduce the expression.Conclusion GP could protect the cerebral ischemia reperfusion in rats and the mechanisms may be related to its anti-oxidation activity of the enzyme,enhance the ability of removing free radicals and reduce the free radical from ischemia-reperfusion" @default.
- W2358622168 created "2016-06-24" @default.
- W2358622168 creator A5027355564 @default.
- W2358622168 date "2013-01-01" @default.
- W2358622168 modified "2023-09-23" @default.
- W2358622168 title "Therapeutic effects of Gypenosides on cerebral ischemia Reperfusion injury in rats" @default.
- W2358622168 hasPublicationYear "2013" @default.
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