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- W2358651421 abstract "To study the immuno-enhancement of genetic adjuvant GM-CSF on somatostatin(SS) DNA vaccine,a total of 40 mice at the age of 22 days were divided into 4 groups and immunized with salt solution(group 1),pcS/2SS(group 2),pGM-CSF/SS(group 3) and pGM-CSF+pcS/2SS(group 4) delivered by attenuated Salmonella at a dose of 10~9CFU per mouse,respectively.A booster was given 2 weeks later with same dosage and method.The results are as follows: Lymphocyte proliferation response of group 3 was higher than the others,indicating that GM-CSF can enhance lymphocyte proliferation responses;the GH level in plasma of group 3 and IGF-Ⅰ level in plasma of group 4 are higher than that of other groups,and levels of GH and IGF-Ⅰbegin to rise at the 2nd and 4th week post primary immunization,respectively.We conclude that genetic adjuvant GM-CSF can enhance immuno-function of somatostatin DNA vaccine.Immune response of fusion-expression plasmid of GM-CSF and SS is superior to that of co-immunization of pGM-CSF+pcS/2SS." @default.
- W2358651421 created "2016-06-24" @default.
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- W2358651421 date "2006-01-01" @default.
- W2358651421 modified "2023-09-25" @default.
- W2358651421 title "Lymphocyte Proliferation and GH,IGF-ISecretion of Mice Immunized with Fusion-Expression Plasmid of GM-CSF and Somatostatin Delivered by Attenuated Salmonella" @default.
- W2358651421 hasPublicationYear "2006" @default.
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