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- W2358653238 abstract "Objective To study the relationship between doses of ultrasound contrast agent(UCA)and contrast-enhancement effects of gray-scale imaging in normal women uterus and to obtain quantitative analytic methods of UCA in normal uterus.Methods SonoVueTM in four different doses(A:0.003 ml/kg;B:0.006 ml/kg;C:0.009 ml/kg and D:0.012 ml/kg)was applied respectively to 10 normal women with intravenous bolus injection.The images were produced using the contrast pulse sequence(CPS)and saved in MO diskette.Then,the data from the images were obtained by offline software apparatus-Paragon release(revision 8.0)and the Gamma function was used to simulate the time-intensity curves by statistic methods(Statistica 6.0).Correspondent parameters from time-intensity curve including:arriving time(AT),time to peak intensity(PIT),peak signal intensity(PI),mean transit time(MTT)and area under the curve(AUC)were calculated by mathematic methods.Student's t-test was used to compare the difference of parameters in the 4 groups.Results The AT and PIT were increased along with the dosage range from 0.003 ml/kg to 0.012 ml/kg in the present study and significant differences(P0.05)were observed among the 4 dosage groups.Also,the PI,MTT and AUC were increased along with the dosage from 0.003 ml/kg to 0.009 ml/kg and significant differences were found among these groups(P0.05).No significant differences were observed from the doses of 0.009 ml/kg to 0.012 ml/kg,though PI,MTT and AUC were increased with doses in two dosage groups(A to C and B to C).Conclusions The parameters of time-intensity curves are affected intensively by different doses of UCA and the dose of 0.009 ml/kg appears to be the optimal dose for uterus perfusion according to our present results." @default.
- W2358653238 created "2016-06-24" @default.
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- W2358653238 date "2007-01-01" @default.
- W2358653238 modified "2023-09-23" @default.
- W2358653238 title "Relationship of dosage-response to contrast-enhanced sonography in normal women uterus:primary study" @default.
- W2358653238 hasPublicationYear "2007" @default.
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