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- W2358654987 abstract "AIM: To study the effect of Vit D_3 on breast cancer in nude mouse xenograft models. METHODS: Each Balb/c nude mouse was injected subcutaneously with human breast cancer cell line MCF-7. Two thousand units of Vit D_3 was injected in mice thigh muscle every other day and mice were fed with tamoxifen (5 mg/kg) every day. Forty experimental mice were randomly divided into 4 groups: Vit D_3 group, the mixed group of Vit D_3 and tamoxifen, tamoxifen group and control group. After 4 weeks, the tumor volume was measured and serum calcium and phosphorus levels were assayed. Tumor cells were analyzed with flow cytometery to detect apoptosis and cell cycle. RESULTS: Serum calcium levels in Vit D_3 group were higher than those in control group(2.54±0.05 vs 2.32±0.09 mmol/L, P0.05), but phosphorus levels were lower(1.78±0.13 vs 2.34±0.06 mmol/L, P0.05). The apoptosis rate (%) of tumor cells in Vit D_3 group was higher than that of control group (31.5±6.9 vs 7.8±2.5, P0.05) and tumor cells were arrested in G_0/G_1 phase(50.0±3.2 vs 34.2±4.7, P0.05), especially in the mixed group treated with Vit D_3 and tamoxifen. CONCLUSION: Vit D_3 has some synergic effect with tamoxifen and can significantly induce apoptosis of breast cancer cells and arrest tumor cells in G_0/G_1 phase." @default.
- W2358654987 created "2016-06-24" @default.
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- W2358654987 date "2006-01-01" @default.
- W2358654987 modified "2023-09-23" @default.
- W2358654987 title "Effect of vitamin D_3 on growth of breast cancer in nude mouse xenograft models" @default.
- W2358654987 hasPublicationYear "2006" @default.
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