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- W2358671574 abstract "In order to explore the cause of aerobic glycolysis in tumor cells,human hepatocarcinoma SMMC-7721 cells were used as model,HIF-1α expression was analyzed by western blotting.The results showed that human liver cancer SMMC-7721 cell plus a dose of sodium nitrite could promote cell proliferation and expression of HIF-1α,but beyond a certain dose of sodium nitrite,proliferation and HIF-1α expression of the cells were inhibited.While nitrite sodium and nitric oxide specific scavenger c-PTIO combined to treat the cells,proliferation and the expression of HIF-1α overall decline,but the low-dose stimulation and high dose inhibition phenomenon of the cell proliferation and the expression of HIF-1α were still existed.The results suggest that sodium nitrite and NO common block mitochondrial respiratory chain,resulting in cellular oxygen consumption decreased and HIF-1α expression increased,then enhance aerobic glycolysis to promote cell proliferation." @default.
- W2358671574 created "2016-06-24" @default.
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- W2358671574 date "2010-01-01" @default.
- W2358671574 modified "2023-09-24" @default.
- W2358671574 title "Effects of Sodium Nitrite on the Protein Expression of HIF-1α in SMMC-7721 Cells" @default.
- W2358671574 hasPublicationYear "2010" @default.
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