FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2358674273> ?p ?o ?g. }

• W2358674273 endingPage "242" @default.
• W2358674273 startingPage "230" @default.
• W2358674273 abstract "Colorectal cancer is the third most frequent cancer worldwide. Overall survival rates have improved greatly over the last few years due, at least in part, to the addition of targeted therapies to standard of care chemotherapy. Angiogenesis plays an important role in colorectal cancer, and therapies directed against the vascular endothelial growth factor (VEGF) axis have contributed significantly to improving the outcome of patients with metastatic colorectal cancer. Over the past few years, several new targeted antiangiogenic agents have been approved for this patient population, confirming the value of inhibiting tumour angiogenesis. The most recent among them is ramucirumab, a fully humanized monoclonal antibody that targets the extracellular domain of VEGF receptor 2. It has proven valuable in multiple tumour types including colorectal cancer. Several phase I and II clinical trials showed a favourable toxicity profile and promising clinical antitumour efficacy in colorectal cancer patients. In the phase III RAISE clinical trial, the addition of ramucirumab to FOLFIRI-based chemotherapy resulted in an improvement of overall survival in patients with metastatic colorectal cancer who had been previously treated with bevacizumab, oxaliplatin and a fluoropyrimidine. On the basis of these results, ramucirumab was approved by the US Food and Drug Administration for this setting. We present an overview of the key preclinical and clinical studies in the development of ramucirumab in the context of metastatic colorectal cancer." @default.
• W2358674273 created "2016-06-24" @default.
• W2358674273 creator A5015190461 @default.
• W2358674273 creator A5054454777 @default.
• W2358674273 creator A5082191671 @default.
• W2358674273 date "2016-03-11" @default.
• W2358674273 modified "2023-10-18" @default.
• W2358674273 title "Ramucirumab in metastatic colorectal cancer: evidence to date and place in therapy" @default.
• W2358674273 cites W1586129343 @default.
• W2358674273 cites W1604140953 @default.
• W2358674273 cites W172183759 @default.
• W2358674273 cites W1756949381 @default.
• W2358674273 cites W1867019634 @default.
• W2358674273 cites W1970730148 @default.
• W2358674273 cites W1980725734 @default.
• W2358674273 cites W1989042510 @default.
• W2358674273 cites W1996550260 @default.
• W2358674273 cites W2000292756 @default.
• W2358674273 cites W2000307014 @default.
• W2358674273 cites W2034269086 @default.
• W2358674273 cites W2035181064 @default.
• W2358674273 cites W2049852228 @default.
• W2358674273 cites W2069092801 @default.
• W2358674273 cites W2077129920 @default.
• W2358674273 cites W2078605907 @default.
• W2358674273 cites W2079292309 @default.
• W2358674273 cites W2081633887 @default.
• W2358674273 cites W2097409998 @default.
• W2358674273 cites W2098243386 @default.
• W2358674273 cites W2098354753 @default.
• W2358674273 cites W2103789431 @default.
• W2358674273 cites W2115735904 @default.
• W2358674273 cites W2121432337 @default.
• W2358674273 cites W2121847974 @default.
• W2358674273 cites W2125447919 @default.
• W2358674273 cites W2125913015 @default.
• W2358674273 cites W2133399075 @default.
• W2358674273 cites W2140868957 @default.
• W2358674273 cites W2147834058 @default.
• W2358674273 cites W2150866539 @default.
• W2358674273 cites W2153297361 @default.
• W2358674273 cites W2157769714 @default.
• W2358674273 cites W2160373161 @default.
• W2358674273 cites W2166573361 @default.
• W2358674273 cites W2184879005 @default.
• W2358674273 cites W2304399644 @default.
• W2358674273 cites W2510143637 @default.
• W2358674273 cites W4252851641 @default.
• W2358674273 doi "https://doi.org/10.1177/1758834016635888" @default.
• W2358674273 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4872251" @default.
• W2358674273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27239240" @default.
• W2358674273 hasPublicationYear "2016" @default.
• W2358674273 type Work @default.
• W2358674273 sameAs 2358674273 @default.
• W2358674273 citedByCount "54" @default.
• W2358674273 countsByYear W23586742732016 @default.
• W2358674273 countsByYear W23586742732017 @default.
• W2358674273 countsByYear W23586742732018 @default.
• W2358674273 countsByYear W23586742732019 @default.
• W2358674273 countsByYear W23586742732020 @default.
• W2358674273 countsByYear W23586742732021 @default.
• W2358674273 countsByYear W23586742732022 @default.
• W2358674273 countsByYear W23586742732023 @default.
• W2358674273 crossrefType "journal-article" @default.
• W2358674273 hasAuthorship W2358674273A5015190461 @default.
• W2358674273 hasAuthorship W2358674273A5054454777 @default.
• W2358674273 hasAuthorship W2358674273A5082191671 @default.
• W2358674273 hasBestOaLocation W23586742731 @default.
• W2358674273 hasConcept C121608353 @default.
• W2358674273 hasConcept C126322002 @default.
• W2358674273 hasConcept C143998085 @default.
• W2358674273 hasConcept C2776694085 @default.
• W2358674273 hasConcept C2777802072 @default.
• W2358674273 hasConcept C2779551604 @default.
• W2358674273 hasConcept C2780394083 @default.
• W2358674273 hasConcept C2780962732 @default.
• W2358674273 hasConcept C2908647359 @default.
• W2358674273 hasConcept C526805850 @default.
• W2358674273 hasConcept C535046627 @default.
• W2358674273 hasConcept C71924100 @default.
• W2358674273 hasConcept C99454951 @default.
• W2358674273 hasConceptScore W2358674273C121608353 @default.
• W2358674273 hasConceptScore W2358674273C126322002 @default.
• W2358674273 hasConceptScore W2358674273C143998085 @default.
• W2358674273 hasConceptScore W2358674273C2776694085 @default.
• W2358674273 hasConceptScore W2358674273C2777802072 @default.
• W2358674273 hasConceptScore W2358674273C2779551604 @default.
• W2358674273 hasConceptScore W2358674273C2780394083 @default.
• W2358674273 hasConceptScore W2358674273C2780962732 @default.
• W2358674273 hasConceptScore W2358674273C2908647359 @default.
• W2358674273 hasConceptScore W2358674273C526805850 @default.
• W2358674273 hasConceptScore W2358674273C535046627 @default.
• W2358674273 hasConceptScore W2358674273C71924100 @default.
• W2358674273 hasConceptScore W2358674273C99454951 @default.
• W2358674273 hasIssue "3" @default.
• W2358674273 hasLocation W23586742731 @default.
• W2358674273 hasLocation W23586742732 @default.
• W2358674273 hasLocation W23586742733 @default.

• next