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- W2358676781 abstract "Objective:To investigate the effect of atorvastatin on endothelial function of normocholesterolaemia patients with chronic heart failure(CHF).Methods:A total of 52 CHF patients participated the double-blind、crossover study by adding placebo(control group)or atorvastatin(40mgd,atorvastatin group) for 6 weeks without changed the medicine their usually used.The blood vessel endothelial function,vascular neurohormone and echocardiography were detected before and after the treatment.Results:Compared with control group,the flow-mediated dilatation(FMD)increased(P0.01) and non-endothelial-dependent vasodilation also increased(P0.05) in atorvastatin group;②Compared with control group,atorvastatin decreased the plasma concentrations of C-type natriuretic peptide and endothelin 1,and increased the plasma concentrations of NO,calcitonin gene-related peptide(P0.01 all);③Compared with control group,atorvastatin decreased the left ventricular end-systolic diameter and increased the left ventricular ejection fraction and cardiac output(P0.01 all).Conclusion:Adding atorvastatin based above conventional therapy further more improves vascular endothelial function and hemodynamics in CHF patients except decrease blood lipid concentrations." @default.
- W2358676781 created "2016-06-24" @default.
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- W2358676781 date "2010-01-01" @default.
- W2358676781 modified "2023-09-24" @default.
- W2358676781 title "Effect of atorvastatin on endothelial function of normocholesterolaemia patients with chronic heart failure" @default.
- W2358676781 hasPublicationYear "2010" @default.
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