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- W2358695514 abstract "Objective To investigate the relationship between plasminogen activator inhibitor-1 and diabetic nephropathy.Methods 94 type 2 diabetic patients was divided into diabetes without nephropathy(the urine albumin excretion rate(UAER)20 μg/min),diabetes with microalbuminural(20 μg/min UAER200 μg/min) and diabetes with multialbuminural(UAER200 μg/min).The levels of PAI-1,serum glucose,serum fasting insulin level and triglyceride were examined in all the diabetic patients and 26 healthy volunteers.Results ①The level of PAI-1 activity increased in type 2 diabetes mellitus compared with controls.②The level of PAI-1 activity significantly increased in the group with diabetic nephropathy,and closely correlated with UAER.③The level of PAI-1 activity was correlated with UAER,homeostasis model assessment-insulin resistance index(HOME-IRI),serum fasting insulin level(FI),triglyceride(TG) and body weight index(BMI).Conclusion High level of PAI-1 activity was a risk of diabetic nephropathy,the insulin resistance,hypertriglyceridemia and obesity were important factors influencing PAI-1." @default.
- W2358695514 created "2016-06-24" @default.
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- W2358695514 date "2006-01-01" @default.
- W2358695514 modified "2023-09-25" @default.
- W2358695514 title "The relationship between plasminogen activator inhibitor-1 and diabetic nephropathy" @default.
- W2358695514 hasPublicationYear "2006" @default.
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