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- W2358708257 abstract "Objective To study the relationship between the expression of HDAC1 and Oct4. Methods A statistical analysis of 661 intestinal-type gastric cancer(ITGC) specimens and the corresponding non-cancerous tissues was performed on the basis of immunohistochemistry results. Overall survival was assessed by survival analysis. Results The immunohistochemistry results showed that Oct4 expression was significantly related to tumor size, regional node metastasis, cell differentiation, HDAC1 expression(P0.001) and invasion depth(P= 0.003). The high expression rate of HDAC1 in Oct4-positive and negative tumor samples was 66.0% and 34.0% respectively, there was a significantly positive correlation between the expression of HDAC1 and Oct4(P0.001). Survival analysis showed that the overall survival(OS) of patients with negative Oct4 expression was significantly better than patients with positive Oct4 expression in ITGC(P0.001), OS of patients with negative Oct4/low HDAC1 expression was significantly better than other combinations(P0.001). Conclusion The expression of Oct4 and HDAC1 have a significantly positive correlation in ITGC. Targeted inhibition of both Oct4 and HDAC1 is promising to lead to longer overall survival." @default.
- W2358708257 created "2016-06-24" @default.
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- W2358708257 date "2013-01-01" @default.
- W2358708257 modified "2023-09-23" @default.
- W2358708257 title "Study on the relationship between the expression of HDAC1 and Oct4 in intestinal-type gastric cancer" @default.
- W2358708257 hasPublicationYear "2013" @default.
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