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- W2358724432 abstract "Aim To investigate effects and the mechanism of rutoside (Ru) on lung injury during experimental acute pancreatitis (AP) . Methods The model of AP was induced by retrograde injection of Sodium Taurocholate(STC)into biliopancreatic duct in rat. Ru (15,30,60 mg·kg -1 ·h -1 ) was administered by intravenous infusion for 6 hours immediately after the induction of AP. Indexes of blood gas analysis, the wet/dry lung ratio and pathological changes of lung tissue were observed and we also measured levels of TNF-α, ICAM-1and NF-κB. Result Ru(60 mg·kg -1 )increased the arterial PO_2, which decreased in AP rats. Ru (30,60 mg·kg -1 ) could decrease the wet/dry lung ratio, and improve pathological changes of lung tissue. Ru(15,30,60 mg·kg -1 ) could decrease levels of TNF-α, ICAM-1, and NF-κB. Conclusion The study indicates that Ru administered by intravenous infusion exerts certain protective effects on lung injury in experimental AP rats by decreasing levels of TNF-α, ICAM-1 and NF-κB." @default.
- W2358724432 created "2016-06-24" @default.
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- W2358724432 date "2006-01-01" @default.
- W2358724432 modified "2023-09-23" @default.
- W2358724432 title "Protective effects and mechanism of Rutoside on lung injury during experimental acute pancreatitis" @default.
- W2358724432 hasPublicationYear "2006" @default.
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