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- W2358730370 abstract "Objective: To preliminarily study effects and the possible mechanism of catgut embedding therapy and Tangtong drink on early DN rats. Methods: Sixty SD rats were randomly divided into the normal group( 12 rats) and the model group. The model group received intraperitoneal injection of STZ combined with high energy diet to establish early DN rats model. After model building,these model rats were divided into non-treatment group( 12 rats),and treatment group including Chinese medicine group,embedding group and the embedding plus Chinese medicine group,12 rats in each group. The treatment lasted 4 weeks and normal group and model group received intragastric administration of normal saline for 4 weeks. 72 hours after treatment,all rats were killed and the tail blood was collected to detect FBG level and serum TGF-β1,IGF-1level. Meanwhile,the rats' kidney tissue was taken to calculate the KHI. Results: Compared with non-treatment group,the FBG level and serum TGF-β1,IGF-1 level of the treatment group( Chinese medicine group,embedding group and the embedding plus Chinese medicine group) decreased significantly( P 0. 01),of which,the embedding plus Chinese medicine group showed the most significant decrease. The kidney hypertrophy index( KHI) in rats of treatment group were significantly reduced compared with the non-treatment group( P 0. 01). Conclusions: Catgut embedding therapy and Tangtong drink can reduce early DN rats'FBG level,TGF-β1level,IGF-1 level,and KHI. It is an effective method for the prevention and treatment of early DN." @default.
- W2358730370 created "2016-06-24" @default.
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- W2358730370 date "2015-01-01" @default.
- W2358730370 modified "2023-09-26" @default.
- W2358730370 title "Effect of Catgut Embedding Therapy and Tangtong Drink on TGF-β_1 and IGF-1 Level of Early Diabetic Nephropathy Rats" @default.
- W2358730370 hasPublicationYear "2015" @default.
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