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- W2358730824 abstract "OBJECTIVE To establish a method to determine the concentration of Phenobarbital(PB),phenytoin-sodium(PT) and carbamazepine(CBZ) in the human plasma,and determine the samples in our hospital with this method.METHODS The high performance liquid chromatography(HPLC) was used.The analysis conditions were as follows:acetonitrile-buffer salt solution(30:70) as mobile phase,column oven temperature 37℃,wavelength 220 nm and flow rate 0.7 mL·min-1.Internal standard method was developed to analyze the content of drugs,and normalization method was developed to analyze the content of impurity.RESULTS The linear ranges were 4.58-75.88 mg·L-1,2.25-35.95 mg·L-1 and 1.26-20.08 mg·L-1 for PB,PT and CBZ,respectively.The RSD within-day and between-days were both less than 10.0%.The average rate of recovery can be controlled in 85%-115%.CONCLUSION This method is simple,rapid,stable,with good accuracy,precision and high sensitivity." @default.
- W2358730824 created "2016-06-24" @default.
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- W2358730824 date "2009-01-01" @default.
- W2358730824 modified "2023-09-28" @default.
- W2358730824 title "Blood Concentration Determination of Anti-epileptic Drugs in Our Hospital" @default.
- W2358730824 hasPublicationYear "2009" @default.
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