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- W2358731632 abstract "Objective To study the changes of platelet function in patients with hypertensive disorder complicating pregnancy (HDCP). Methods Forty non-pregnant women, 40 normal late pregnant women and 50 women with HDCP were in cluded in this study. Platelet count were determined by cell-DYN, the platelet alphagranule membrane protein (GMP-140) by radio-immunoassay and thrombosis bla smixgenz (TXB_2) and βtissue platelet protein (β-tg) by ELISA. Platelet aggregation rate (Pagt) and pletelet adhesion rate (PADT) were also measured. Results The platelet count in non-pregnant, late pregnant and HDCP group were (206±48)×109/L, (204±52)×109/L and (172±51)×109/L, respectively, and that in the HDCP group was significantly lower than the other two. The levels of GMP-140, TXB_2, β-TG, PAdT and PAgT were (7.9±2.8) μg/L, (73.6±40.8) ng/L, (16.3±9.5) μg/L, (18±9)% and (28±10)% in the non-pregnant group, (12.2±3.8) μg/L, (80.0±39.6) μg/L, (18.5±9.8) μg/L, (20±8)% and (29±10)% in the late pregnant group and (25.1±3.8) μg/L, (107.6±32.8) ng/L, (23.9±9.2) μg/L, (30±10)% and (40±12)% in the HDCP group. All the above values in the HDCP group were significantly higher than those in the other two groups (P0.05 or P0.01), and the value of GMP-140, TXB_2 and β-TG in the late pregnant group were significantly higher than those in the non pregnant group (P0.05). Conclusions The change of platelet activation, adhesion and aggregation may participate in the onset and progress of HDCP." @default.
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- W2358731632 date "2006-01-01" @default.
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- W2358731632 title "Study on the changes of platelet function in patients with hypertensive disorder complicating pregnancy" @default.
- W2358731632 hasPublicationYear "2006" @default.
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