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- W2358732246 abstract "Objective To investigate the roles and the clinical significance of IGF-1 and IGFBP-3 in the pathogenesis of colon cancer. Methods The expression levels of IGF-1 and IGFBP-3 were detected by immunohistochemistry( SP) in 78 cases of colorectal carcinoma tissues( CRC group) and 78 cases of normal colon mucosa tissues( control group). Results The positive expression rate of IGF-1 was 57. 7% in colon cancer group,which was significantly higher than that( 25%) in control group( P 0. 01). However the positive expression rate of IGFBP-3 was 73. 1% in CRC group,which was significantly lower than that( 89. 7%) in control group( P 0. 01). The expression of IGF-1in colon cancer tissues was closely correlated to infiltration depth of tumor,TNM staging and lymph node metastasis( P 0. 05),and the expression of IGFBP-3 in colon cancer was related with TNM staging,lymph node metastasis as well as distant metastasis( P 0. 05),however,the expressions of both IGF-1 and IGFBP-3 were not correlated to the other factors( P 0. 05). The expression of IGF-1 was negatively related with that of IGFBP-3( P 0. 05). Conclusion IGF-1 and IGFBP-3 play an important role in the pathogenesis and development of colon cancer,and the two factors are related with multi-parameters about prognosis. The combined detection of IGF-1 and IGFBP-3 may become one of biological indexes for evaluating prognosis of patients with colon cancer." @default.
- W2358732246 created "2016-06-24" @default.
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- W2358732246 date "2014-01-01" @default.
- W2358732246 modified "2023-09-25" @default.
- W2358732246 title "Expressions and clinical significance of IGF-1 and IGFBP-3 in colon cancer" @default.
- W2358732246 hasPublicationYear "2014" @default.
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