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- W2358756502 abstract "Objective To explore mercury accumulation in KM mice following long-term use of Zuotai(gTso thal) and provide scientific basis for safety use of Zuotai in clinic.Methods KM mice were randomly divided into control groups and Zuotai groups,and the Zuotai groups were treated with Zuotai 6.67 mg.kg-1 bwday for 4.5 months and drug discontinuance for 1.5 months.Blood,kidneys,brains,livers and spleens of mice were taken out every half month and the mercury content was measured.Results The accumulation of mercury in kidney in Zuotai groups was varied obviously compared with control groups,38.24 ng /g at 1.5 months and 84.68 ng / g at 3 months,the content of mercury become normal 31.46 ng / g when drug discontinuance for 1.5 months;the amount of mercury in brain was 23.60 ng / g at 2 months and was higher till 4.5 months,but the data were fluctuating.The mercury content in blood,liver and spleen didn't vary strikingly compared with control groups and the amount of mercury decreased when drug discontinuance.Conclusion The mercury can be accumulated in kidney.The amount of mercury is higher in brain of Zuotai groups than control groups and won't accumulate in blood,liver and spleen of KM mice following long-term treatment of clinical dose Zuotai,and the level of mercury can descent when drug discontinuance." @default.
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- W2358756502 date "2012-01-01" @default.
- W2358756502 modified "2023-09-23" @default.
- W2358756502 title "The Chronic Accumulation of Mercury in Tibetan Medicine Zuotai( gTso thal)" @default.
- W2358756502 hasPublicationYear "2012" @default.
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