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- W2358758110 abstract "Objective To explore the influence of tripterygium wilfordii(TW) on urine podocyte excretion in patients with diabetic nephropathy(DN). Methods Thirty DN patients were enrolled in this study,who were hospitalized or outpatients of department of endocrinology or nephrology of the Affiliated Hospital during 10.2009—02.2010.All the patients had a normal level of serum creatinine,and their 24-hour urinary microalbuminuria was higher than 300 mg.The patients were randomly divided into three groups as treatment group,positive control group and control group.All the patients received supportive treatment to control the blood glucose,blood pressure and blood fat.Patients in the treatment group received additionally 1 mg/(kg·d) of TW,and those in the positive control group received Irbesartan tablets at the dose of 300 mg/d,the course of treatment was eight weeks for both groups.Podocytes in urine sediments were detected by indirect immunofluorescence before and after the treatment.Results The number of podocytes in all patients decreased after treatment(t=9.00-14.70,P0.01).The number of podocytes in the treatment group and positive control group was fewer than that in the control group after treatment(F=3.92;q=2.20,2.50;P0.01),and that of the difference between the positive control group and treatment group was not significant(P0.05).Conclusion Tripterygium wilfordii can significantly reduce the excretion of urine podocytes,thus reduce the injury of podocytes,and protect the kidneys." @default.
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- W2358758110 date "2011-01-01" @default.
- W2358758110 modified "2023-09-27" @default.
- W2358758110 title "THE INFLUENCE OF TRIPETERYGIUM WILFORDII ON URINE PODOCYTE EXCRETION IN PATIENTS WITH DIABETIC NEPHROPATHY" @default.
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