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- W2358776910 abstract "Objective] To study the effect of ginkgo bibloba extract (EGb) ,an antioxidant, on liver fibrosis in rats . [Methods] The experimental hepatic fibrosis was induced by intraperitoneal injection of carbon tetrachloride (CCl_4). EGb was administrated to the treatment group for 8 weeks. Control group received saline. Changes of liver pathology,liver function were compared. Expression of α-SMA, TGF-β_1 and collagen type I in the liver tissue were measured by SP immunohistochemistry method. Expression of TGF-β_1, collagen type I and TIMP_1 mRNA were tested by RT-PCR. [Results] Compared with the model group, in the treatment group the expression of α-SMA, TGF-β_1, collagen type I and TIMP_1 reduced ( P0.01), liver function improved ( P0.01), fibrosis degree of the liver ameliorated and the areas of collagen fiber and reticulum fiber decreased obviously ( P0.01).[Conclusion]EGb could reverse the pathologic development of fibrosis. The mechanism possibly contributed to its anti-lipoperoxidation and hepatocyte protection effect, suppressing the activation of hepatic stellate cells and the synthesis of TGF-β_1, collagen type I and TIMP_1." @default.
- W2358776910 created "2016-06-24" @default.
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- W2358776910 date "2005-01-01" @default.
- W2358776910 modified "2023-09-25" @default.
- W2358776910 title "Experimental study on ginkgo bibloba extract reversing carbon tetrachloride-induced liver fibrosis in rats" @default.
- W2358776910 hasPublicationYear "2005" @default.
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