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- W2358779152 abstract "Objective To study the expression of Rac1 and hypoxia inducible factor-1α(HIF-1α) in tissues of experimental choroidal neovascularization(CNV) model in mice and its significance.Methods CNV models were induced by 532 nm laser,the eyeballs were taken out on the 1st,3rd,7th,14th and 28th day respectively after fluorescein angiography was performed.The expression of Rac1 and HIF-1α in CNV tissues was detected by immunohistochemistry.Results Rac1 and HIF-1α proteins were negative in normal retinal and choroidal tissues,but which were both significantly expressed in tissues of experimental CNV model induced by 532 nm laser.Their expression both increased during the earlier period after photocoagulation.The positive expression rates of Rac1 and HIF-1α were 11.21% and 24.80% respectively on the 1st day after laser,and achieved the peak on the 3rd and 7th day,when the positive expression rates of Rac1 were 34.58% and 53.35%,and that of HIF-1α were 33.05% and 50.35% respectively.On the 14th day,the expression of Rac1 and HIF-1α both decreased,the rates of which were about 25.50% and 31.97% respectively.On the 28th day,the positive expression rates of Rac1 and HIF-1α were 9.32% and 11.26% respectively.There was obvious correlation between the expression of Rac1 and HIF-1α(r=0.943,P=0.016).Conclusion Rac1 and HIF-1α are significantly expressed in tissues of experimental CNV model,and one is closed correlated with the other." @default.
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- W2358779152 date "2007-01-01" @default.
- W2358779152 modified "2023-09-23" @default.
- W2358779152 title "Expression of Rac1 and HIF-1 in tissues of choroidal neovascularization model induced by laser in mice" @default.
- W2358779152 hasPublicationYear "2007" @default.
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