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- W2358784135 abstract "Objective The aim of this study is to explore the distribution and determinants of plasma total homocysteine(tHcy) concentrations in type 2 diabetes patients with and without diabetic nephropathy,and to assess the relationship between high tHcy and diabetic nephropathy.Methods We studied 242 type 2 diabetes patients including 34 with macroalbuminuria(group1),60 with microalbuminuria(group2),148 with normal microalbuminuria(group3),and 140 with normal glucose tolerance served as normal controls(group4).Basic material are investigated,and Fasting blood and Urine samples are collected for measurement.Creatinine clearance(Ccr) is estimated by Cockcroft-Gault formula and insulin resistance is calculated by the homeostasis model assessment(HOMA).Results The level of tHcy in group1,group2 and group3 are significantly higher than that in group4(16.9±5.0 μmol/L,13.4±3.7 μmol/L,11.8±4.2 μmol/L vs 11.0±6.0 μmol/L,P0.001).The same consequence is also found for the prevalence of hyperhomocysteinemia(HHe) in four groups(group1:58.8%,group2:36.4%,group3:15.5%,vs group4:7.9%,P0.001).There is a significant decreasing trend of serum folate and VitB_(12)from group4 to group1(P0.001).In patients with type 2 diabetes(group1,2,3,n=242),using multivariate linear regression,the age,folate,VitB_(12) and Scr are independent predictors of lg tHcy(R=0.613,R~2=0.376).The risk factors for diabetic nephropathy are evaluated by binary logistic regression.The increment of tHcy(per 5.0 μmol/L tHcy) resulted in a markedly elevated risk for diabetic nephropathy(OR:2.041,95% CI:1.377-3.024) in type 2 diabetes patients.Conclusion Compared with normal controls,the level of tHcy and the prevalence of HHe significantly increase in type 2 diabetes with normal microalbuminuria,and have a considerably increasing trend with the development of diabetic nephropathy.The increased plasma tHcy is one of the risk factors for diabetic nephropathy in type 2 diabetes.The level of plasma tHcy should be monitored in type 2 diabetes patients with and without diabetic nephropathy" @default.
- W2358784135 created "2016-06-24" @default.
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- W2358784135 date "2006-01-01" @default.
- W2358784135 modified "2023-09-22" @default.
- W2358784135 title "The level of total plasma homocysteine in type 2 diabetes patients with and without diabetic nephropathy" @default.
- W2358784135 hasPublicationYear "2006" @default.
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