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- W2358789215 abstract "Objective To observe the inhibitory effect of midazolam on status epilepticus(SE) induced by tetramine in rats and its influence on expression of GABAA receptor α1 subunit in cortex and hippocampus.Methods Sixty SD rats were randomly divided into 6 groups(10 each):normal control group,positive control group,SE group,and midazolam 10,20,30mg/kg groups.SE was induced by tetramine(1.2mg/kg) in rat,and its typical epileptic waves and survival rate of rats served as observation indexes.The anti-epileptic effects of different dosages of midazolam(10,20,30mg/kg) injected intraperitoneally were observed.Diazepam was employed as the positive control drug.The effect of 20mg/kg midazolam on the expression of GABAA receptor α1 subunit in the cortex and hippocampas 24h after seizures was determined by Western blotting.Results 1.2mg/kg tetramine could readily induce SE,with EEG showing high-frequency and high-amplitude spike waves continuously.20 and 30mg/kg midazolam alleviated the seizure effectively,with the frequency and amplitude of eclampsia waves degraded significantly 10min after midazolam administration.Eclampsia waves disappeared 1h after midazolam administration without reappearance within 5 hours.The survival rates of midazolam 20 and 30mg/kg groups were obviously higher than that of SE group(P0.01).In midazolam 10mg/kg group,the high-frequency and high-amplitude eclampsia waves could still be observed,and the survival rate was similar to that of SE group(P0.05).The expression of GABAA receptor α1 subunit was significantly down regulated in cortex and hippocampus 24 hours after SE occurrence,and increased significantly in midazolam 20mg/kg group,and it was higher than that of normal control group and SE group(P0.01).Conclusion Midazolam can efficiently inhibit the seizure of status epilepticus induced by tetramine,and may used as first or second line drug in clinical practice.The efficacy of midazolam may be attributable to the up-regulated expression of GABAA receptor α1 subunit." @default.
- W2358789215 created "2016-06-24" @default.
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- W2358789215 date "2009-01-01" @default.
- W2358789215 modified "2023-09-26" @default.
- W2358789215 title "Inhibitory effect of midazolam on status epilepticus induced by tetramine in rats" @default.
- W2358789215 hasPublicationYear "2009" @default.
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