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- W2358790803 abstract "Aim To discuss the influence of resveratrol on acute phases of focal cerebral ischemic injury in mice and possible mechanisms.Methods Ninety Balb/c healthy male mice,weighting 18~22 g,were randomly divided into three groups:resveratrol group,fenofibrate group and ischemia group.There were thirty mice in each group.The ischemic model of mice was induced with an 8/0 nylon monofilament coated with silicone hardener mixture via the internal carotid artery.24 hours after reperfusion,the infarct area was shown by 2,3,5-triphenyl tetrazolium chlorid(TTC)staining;Evans blue staining was used for showing the damage of blood brain barrier and the express of peroxisome proliferator activated receptor(PPAR)alpha was shown by RT-PCR.Results The infarct volume in resveratrol group and fenofibrate group were lower thanischemia group〔(43.80±5.31)mm3,(45.57±5.63)mm3 vs(63.87±9.33)mm3,P0.01)〕.In resveratrol group and fenofibrate group,the extent and quality of Evans blue extravasation were reduced compared with ischemia group〔(58.66±4.65)mm3,(78.72±5.78)mm3 vs(102.06±6.07)mm3,P0.01〕 and(6.40±0.92)μg·g-1,(12.47±1.24)μg·g-1 vs(15.25±1.51)μg·g-1,P0.01)〕,PPARα mRNAs were prominently expressed compared with ischemia group(0.893±0.028,1.117±0.042 vs 0.467±0.013,P0.01).Conclusion The study suggests that resveratrol has protective effects against acute ischemic stroke,which could be attributed to its property increasing PPARα.Thus,resveratrol may be a potential agent for the treatment of neuronal injury associated with stroke." @default.
- W2358790803 created "2016-06-24" @default.
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- W2358790803 date "2008-01-01" @default.
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- W2358790803 title "Resveratrol's effect on acute phases of focal cerebral ischemic injury in mice" @default.
- W2358790803 hasPublicationYear "2008" @default.
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