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- W2358792904 abstract "Objective To estimate of cyclosporin A (CsA)microemulsion areas under the curve in 20 Chinese healthy volunteers with a limited sampling strategy(LSS). Methods A single dose of CsA microemulsion was administrated to 20 healthy volunteers.The concentration of CsA in whole blood was determined by validated high performance liquid chromatography (HPLC) method. Multilinear regression analysis were performed to establish a model to estimate AUC of CsA by LSS method. The Jacknife procedure were found to be precise and unbias as compared with reference AUC. Results The linearity relationship between AUC and single concentration point was poor. Several models for CsA AUC estimation met the predefined criteria(γ 20.9,P0.05).The AUC of CsA was best estimated by C 2 and C 6.Conclusion A multilinear regression model for estimation AUC of CsA by using LSS method was developed. The method was accuracy and considered desirable for CsA therapeutic drug monitoring." @default.
- W2358792904 created "2016-06-24" @default.
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- W2358792904 date "2005-01-01" @default.
- W2358792904 modified "2023-09-23" @default.
- W2358792904 title "Estimation areas under the curve after oral administration cyclosporin A in healthy volunteers by limited sampling strategy" @default.
- W2358792904 hasPublicationYear "2005" @default.
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