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- W2358800793 abstract "Objective To investigate the effects of 125I seed on the growth and programmed cell death of human glioma cell line SHG-44,and clarify the action mechanism of the related genes in this process. Methods SHG-44 glioma cells were cultivated in vitro,and divided into control group and treatment group.The inhibitory effect of 125I on SHG-44 cell proliferation was determined by MTT method. The morphological changes of SHG-44 cells were examined by electron microscopy,TUNEL method and Acridine Orange/Ethidium bromide double fluorescent staining. The gene expresion profile was established by using gene chip technique. Results 125I seed had inhibitory effect on the proliferation of SHG-44 cells cultivated in vitro in a dose and time-dependent manner.The result of MTT showed that the A value of SHG-44 cells treated with 125I seed was significantly decreased with the increasing of radiation dose and prolongation of time.The inhibitory rate of SHG-44 cells after treated with 125I seed for 3 d was 50%,there was significant difference compared with control group(P0.05). Autophagy was frequently observed under transmission electron microscope in SHG-44 cells.The number of cells at S phase was reduced while the number of cells at G1 and G2/M phase was increased.Although the apoptosis in SHG-44 cells was increased,but not more than 2%. There were 56 differential expression genes of SHG-44 cells after exposure to 125I including 36 up-regulation genes and 20 down-regulation genes. Conclusion 125I seed can inhibit the proliferation of SHG-44 glioma cells in a dose-dependent manner by inducing the programmed cell death. There may be non-apoptotic programmed cell death (autophagy) in SHG-44 glioma cell line after induction by 125I at relatively low concentration. These results suggest that the mechanism of 125I-induced proliferation inhibitory effect and apoptosis in SHG-44 cells may be related to the genes of p53 and ATM pathway,C-myc family ,p16 family ,Bcl-2 family,TNF ligand family and TNF receptor family genes." @default.
- W2358800793 created "2016-06-24" @default.
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- W2358800793 date "2010-01-01" @default.
- W2358800793 modified "2023-09-22" @default.
- W2358800793 title "Effects of ~(125)I on programmed cell death and expressions of genes related to programmed cell death in glioma cell line SHG-44" @default.
- W2358800793 hasPublicationYear "2010" @default.
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