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- W2358818333 abstract "Objective:To compare the clinical efficacy of mycophenolate mofetil (MMF) versus pulse cyclophosphamide (CTX) therapy in the treatment of severe Henoch-Schonlein purpura nephritis (HSPN). Methodology:Thirty-nine patients with severe HSPN proven clinically and histologically were enrolled into this study. They were divided into MMF and CTX groups. MMF group included 21 cases who were treated with MMF at a dosage of 1.5～2.0 g/d. CTX group enrolled 18 cases who were geven 0.6～0.75 g/m~2 BSA monthly for 6 months and then quarterly. The patients in both groups also received methylprednisolone (MP) pulse therapy followed by oral predenisone. The two groups were matched in age and severity of renal damage. One in MMF group and six patients in CTX group were lost follow-up, and two patients in CTX group were dropped out during the therapy. The other patients were followed up for more than 12 months. The clinical efficacy and side effects were compared between the two groups. Results:①Clinical efficacy: The total remission rate (complete remission and partial remission) in the 6~ th, 9~ thand 12~ thmonth after MMF therapy were 65%,85% and 95%, while only 58.3%, 58.3% and 58.3% in CTX group respectively. The complete remission rate in MMF vs CTX Group were 25% vs 8.3%, 40% vs 25% and 50% vs 25%(P0.05),respectively. ②The complete remission rate of proteinuria (≤0.4 g/24h) in the 6~ thand 12~ thmonth after the MMF vs CTX therapy were 45% vs 16.7% and 70% vs 25%(P0.05),respectively. ③The complete remission rate of Urinary RBC count(≤10×10~4/ml) in the 6~ thmonth after the MMF vs CTX therapy were 45% vs 16.7%. ④Renal function:5 of six cases recovered renal function after treatment with MMF for 3 months, and one for 6 months. In CTX group, four cases recovered their renal function after treatment for 3 months. ⑤Side effects: There were no significant side effects in both groups. Only one was dropped out owing to severe side effect in CTX group.⑥Recurrence: Two cases relapsed in MMF group, while five cases relapsed in CTX group. Conclusion:The combination therapy of MMF and steroid was more effective than CTX pulse therapy in patients with severe HSPN. MMF could have more efficacy in reducing proteinuria, haematuria with fewer complications and lower relapse." @default.
- W2358818333 created "2016-06-24" @default.
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- W2358818333 date "2005-01-01" @default.
- W2358818333 modified "2023-09-24" @default.
- W2358818333 title "Mycophenolate mofetil therapy versus intermittent cyclophosphamide pulse treatment in patients with severe Henoch-Schonlein purpura nephritis" @default.
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