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- W2358854751 abstract "Objective To study the interactive effect of serum organochlorine residues and glutathione S-transferase M1(GSTM1) on the risk of breast cancer in women.Methods Seventy newly diagnosed female breast cancer patients and 70 controls were investigated with face-to-face interview.The organochlorine residue level in serum were measured with gas chromatography(GC).Genotypes of GSTM1 polymorphism were analyzed with multiplex allele-specific polymerase chain reaction(PCR).Results Odds ratio(OR) of breast cancer for women with high DDT residue level was 3.859(95% confidence interval=1.195-12.466),and the OR of GSTM1 genetype polymorphism was 1.343(95%CI=0.3553-5.075).The OR of breast cancer for women with the two factors was 5.557(95%CI=1.633-18.903) with an interaction index(r) value of 1.237.The results showed that gene deletion type of GSTM1 enhanced the effect of DDT residue in serum.The OR of breast cancer for women with high hexachlorohexane(HCH) residue level was 2.731(95%CI=0.841-8.869),and the OR of with GSTM1 genetype polymorphism was 1.483(95%CI=0.478-4.603).The OR of the two factors was 3.866(95%CI=1.178-12.682) with an interaction index(r) value of 1.379.The results showed that gene deletion type of GSTM1 enhanced the effect of HCH residues in serum.Conclusion Genetic polymorphisms of GSTM1 and environmental DDT/HCH exposure have an interaction in the development of breast cancer." @default.
- W2358854751 created "2016-06-24" @default.
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- W2358854751 date "2010-01-01" @default.
- W2358854751 modified "2023-09-24" @default.
- W2358854751 title "Relationship between serum organochlorine residues,genetic polymorphism of glutathione S-transferase M1 and breast cancar in women" @default.
- W2358854751 hasPublicationYear "2010" @default.
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