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- W2358902376 abstract "Objective To investigate the relationgship between the promoter hypermethylation of MGMT gene and clinicopathologic feature in NSCLC tissues.Methods Took 77 cases of NSCLC who were treated in Henan Chest Hospital from March 2006 to July 2009 as research subjects,the other 20 cases with benign lung disease as the control group,the methylation specific PCR(MSP) were used to test the methylation status of MGMT in two groups.Results 26 cases of study group had MGMT gene methylation,the incidence rate was 33.8%,while no case of control group occurred MGMT gene methylation,the difference between groups was statistically significant(P0.05);The promoter hypermethylation of MGMT was correlated to the history of smoking,lymph node metastasis,TNM stage was Ⅲ and low degree of tumor differation(P0.05),but not correlated to patient age,gender and histological type(P0.05).Conclusion The promoter hypermethylation of MGMT gene may take part in lung carcinoma evolvement." @default.
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- W2358902376 date "2011-01-01" @default.
- W2358902376 modified "2023-09-23" @default.
- W2358902376 title "Investigation on the relationgship between the promoter hypermethylation of MGMT and clinicopathologic feature in NSCLC tissues" @default.
- W2358902376 hasPublicationYear "2011" @default.
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