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- W2358902462 abstract "Objective To study the effect of tibolone on expression of IL-1β and TNF-α in ovariectomized rats during cerebral ischemia-reperfusion injury.Methods Thirty healthy adult female Sprague Dawley rats were selected and randomly divided into sham-operated group,ovariectomized group,tibolone group 2.5mg/(d·kg).A brain ischemia model was induced by left middle cerebral artery occlusion for 2 hours.All animals were killed 24 hours after reperfusion.Cerebral infarction volume was meausred with 2,3,5 triphenyltetrazlium chloride(TTC)staining and image analysis.The expression of interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)was detected by immunohistochemistry.Changes in tissue pathology were also investigated.Results The cerebral infarction volume was significantly lower in tibolone group than in ovariectomized group(P0.05).The expression of IL-1β and TNF-α was obviously lower in tibolone group than in ovariectomized group(P0.01).Conclusion Tibolone decreases the expression of IL-1β and TNF-α,thus protecting brain tissue against cerebral ischemia-reperfusion injury." @default.
- W2358902462 created "2016-06-24" @default.
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- W2358902462 date "2009-01-01" @default.
- W2358902462 modified "2023-09-26" @default.
- W2358902462 title "Effect of tibolone on IL-1β and TNF-α expression in ovariectomized rats after cerebral ischemia-reperfusion" @default.
- W2358902462 hasPublicationYear "2009" @default.
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