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- W2358903376 abstract "Objective To investigate the effect of formaldehyde inducing DNA damage and DNA-protein cross-links (DPC) in P815 cell line.Methods KCl-SDS assay and comet assay were used to test the effect of DNA damages and the content of DPC induced by liquid formaldehyde in P815 cell line.Results According to the comet assay, DNA strand breakage (DSSB) was caused at low levels (5 μM, 25 μM, P 0.001) and cross-links at higher levels (125 μM, 625 μM, P 0.001). According to the KCl-SDS assay, formaldehyde did not cause DPC at low levels (5 μM, 25 μM, P0.05), howeverat higher levels (125 μM, P 0.05; 625 μM, P 0.001) DPC occurred obviously.Conclusion FA induced DPC of mast cell at higher concentrations, it might induce asthma, and were there any distinct relation between DPC of mast cell and asthma induction needs further study." @default.
- W2358903376 created "2016-06-24" @default.
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- W2358903376 date "2007-01-01" @default.
- W2358903376 modified "2023-09-28" @default.
- W2358903376 title "Relationship between formaldehyde induced DNA damage and asthma induction" @default.
- W2358903376 hasPublicationYear "2007" @default.
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