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- W2358922677 abstract "Objective To investigate the effects of exogenous monosialotetrahexosylganglioside(GM1) and oxaliplatin on human colon cancer HCT116 cell proliferation and cell cycle.Methods The HCT116 cells were incubated with 20 μmol/L oxaliplatin and different concentrations of GM1(5-300 μmol/L) for 12,24 and 48 h,which entailed assessment of the proliferative viability by using CCK-8 assay.An inverted microscope was employed to determine the morphological changes following incubation,and flow cytometry(FCM) was applied to investigate the distribution of cell cycle and apoptosis rate.Results Oxaliplatin significantly inhibited HCT116 cell proliferation in a time-dependent fashion that was not altered by addition of GM1(P0.05).Morphology examination suggested that treatment with oxaliplatin at hour 24 markedly suppressed HCT116 growth,which was not affected by the addition of GM1.The FCM analysis showed that treatment with oxaliplatin at hour 24 resulted in diminished HCT116 cells at stages G0 /G1 and S,increased cell count at stage G2 /M and rate of apoptosis(all P0.05),which were not altered by the addition of GM1(P0.05).Conclusion Exogenous GM1 does not attenuate the inhibitory effects of oxaliplatin on HCT116 cells in vitro nor the cell cycle or apoptosis." @default.
- W2358922677 created "2016-06-24" @default.
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- W2358922677 date "2013-01-01" @default.
- W2358922677 modified "2023-09-23" @default.
- W2358922677 title "Effect of monosialotetrahexosylganglioside and oxaliplatin on human colon cancer HCT116 cell proliferation and cell cycle" @default.
- W2358922677 hasPublicationYear "2013" @default.
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