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- W2358925981 abstract "The main pathology basis underlying symptoms in Parkinson's disease( PD) is a degeneration of nigrostriatal dopamine( DA) neurons. Intrastriatal transplantation of immature DA neurons,which replace those died neurons,leads to functional restoration for PD patients. The prospect for the new clinical trial with transplantation of stem cells is described. we briefly summarize and discuss recent findings of these grafts to the animals and human after implantation. We summarize the attempts to generate DA neurons from stem cells of various sources and patient-specific DA neurons from fully differentiated somatic cells,with particular emphasis on the requirements of these cells to be useful in theclinical setting. Finally,we discuss the underlying graft-induced dyskinesias,ethical problems,and secondary tumor formation which constitute the significant adverse events observed after neural transplantation and wish that there will be methods to develop a competitive cell therapy for PD patients." @default.
- W2358925981 created "2016-06-24" @default.
- W2358925981 creator A5075385787 @default.
- W2358925981 date "2013-01-01" @default.
- W2358925981 modified "2023-09-27" @default.
- W2358925981 title "Research progress of stem cell transplantation for parkinson's disease therapy" @default.
- W2358925981 hasPublicationYear "2013" @default.
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