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- W2358961427 abstract "Background and purpose:Human non-melanocytic skin tumors are the most common forms of skin tumors.Recent studies showed that c-FLIP plays a key role in the development of tumors.This study aimed to investigate the expression of c-FLIP protein in human non-melanocytic skin tumors and its clinical significance.Methods:The immunohistochemical method was used to determine the expression of c-FLIP in 81 human non-melanocytic skin tumors.Results:The positive expressive rate of c-FLIP in 4 research groups are all significantly higher than in the normal control group,and therefore showed a statistical differences(P0.01).The abnormal expression of c-FLIP in four research groups increase with malignancy of these diseases,but there were no statistical differences(P0.05).The abnormal expression of c-FLIP in the SCC stage Ⅱ-Ⅲ were higher than that in the stageⅠ,but there were also no statistical differences(P0.05).The positive expressive rate of c-FLIP in SCC correlated with the extent of infiltration and tumor metastasis(P0.05).Conclusion:c-FLIP proteins play an important role in the genesis and progress of human non-melanocytic skin tumors." @default.
- W2358961427 created "2016-06-24" @default.
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- W2358961427 date "2011-01-01" @default.
- W2358961427 modified "2023-09-23" @default.
- W2358961427 title "Clinical significance and expression of c-FLIP in human non-melanocytic skin tumors" @default.
- W2358961427 hasPublicationYear "2011" @default.
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