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- W2358970131 abstract "Objective To investigate the effects of UVB irradiation and(-)-epigallocatechin-3-gallate(EGCG)protection on apoptosis and death of cultured human keratinocytes(HaCaT cell line),and its association with bcl-2and Fas gene.Methods Flow cytometry was applied to detect the number of apop-totic and dead keratinocytes and the level of bcl-2protein.Fas mRNA was measured by RT-PCR method.Results The numbers of apoptotic and dead cells were significantly higher in all of the UVB irradiation groups than those in normal controls(P 0.01).Compared with42mJ/cm 2 UVB groups,the number of apoptotic cells was much lower(t=2.39,P0.05)and the number of dead cells was much higher(t=4.82,P0.01)in126mJ/cm 2 UVB group.However,there were no significant difference of bcl-2(t=1.30,P0.25)and Fas mRNA(t=0.32,P0.25)levels in the two groups.In the group treated with42mJ/cm 2 UVB irradiation followed by the addition of EGCG,the numbers of apoptotic and dead cells and Fas mRNA were decreased,but bcl-2protein was increased.Conclusions Low dosage of UVB irradiation could induce apoptosis of keratinocytes.High dosage of UVB irradiation might result in cell death.EGCG could reduce UVB-induced apoptosis of keratinocytes by increasing bcl-2protein and decreasing Fas mRNA." @default.
- W2358970131 created "2016-06-24" @default.
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- W2358970131 date "2003-01-01" @default.
- W2358970131 modified "2023-09-23" @default.
- W2358970131 title "Study on the Mechanism of UVB Irradiation and(-)-epigallocatechin-3-gallate Protection on Apoptosis of Cultured Human Keratinocytes" @default.
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