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- W2358977891 abstract "Objective To discuss the negative regulatory effects of CD4+ CD25+ regulatory T cells(Treg) on killer cells in adoptive immunotherapy of the patients with colon cancer.Methods The CD4+T cells were isolated from peripheral blood of 15 patients with colon cancer and 15 health volunteers respectively,and the levels of CD4+CD25+ T cells were determined using flow cytometry and killer effects of cytotoxic T-lymphocyte(CTL) on tumor cells were observed in experiment groups.Results The percentage of CD4+CD25+ regulatory T cells in total CD4+T cells in colon cancer patients was(11.12±0.57)%,which was significantly higher than that in health volunteers(8.77±0.66)%(t=2.687,P=0.012).The killer efficiency of antigen specific CTL in experimental group(33.74±4.42)%,which the CD4+CD25+T cells were removed,was significantly higher than that in control group with CD4+CD25+T cells non-removed(17.39±2.54)%(t=3.206,P=0.0034).Conclusions The contents of CD4+CD25+ regulatory T cells were significantly up-regulated in peripheral blood of the patients with colon cancer and these Tregs cells possessed inhibitory effects on killer function of CTL induced by tumor antigen." @default.
- W2358977891 created "2016-06-24" @default.
- W2358977891 creator A5070964879 @default.
- W2358977891 date "2008-01-01" @default.
- W2358977891 modified "2023-09-26" @default.
- W2358977891 title "Effects of CD4~+ CD25~+ regulatory T cells on adoptive immunotherapy effector cells of colon carcinoma" @default.
- W2358977891 hasPublicationYear "2008" @default.
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