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- W2358988440 abstract "Objective To investigate the role of CD_4~+CD_(25)~+T cells in the pathogenesis of different stages of ulcerative colitis(UC).Methods Fourteen healthy subjects(control group) and 27 UC patients,12 in active stage(UC1 group) and 15 in remission(UC2 group),were enrolled to determine in peripheral blood mononuclear cells(PBMC) the proportion of CD_4~+CD_(25)~+T cells and CD+4T cells by using flow cytometry and the level of Foxp3 mRNA in PBMC by using Roche Light Cycler fluorescence quantitative PCR instrument.Results(1)An increase was observed in the proportion of CD_4~+CD_(25)~+T cells and the level of Foxp3 mRNA,and a significant drop in that of CD+4T cells in UC1 group as compared with control group(P0.05).(2)There was no significant difference in the proportion of CD_4~+CD_(25)~+T cells and CD+4T cells and the level of Foxp3 mRNA between group UC1 and normal control(P0.05),but CD_4~+CD_(25)~+T/CD+4T ratio increased markedly in UC2 group when compared with control group(P0.05).Conclusion The changes of CD_4~+CD_(25)~+T cells play an important role in the pathogenesis of different stages of UC." @default.
- W2358988440 created "2016-06-24" @default.
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- W2358988440 date "2009-01-01" @default.
- W2358988440 modified "2023-09-23" @default.
- W2358988440 title "The Role of CD_4~+CD_(25)~+T Cells in Different Stages of Ulcerative Colitis" @default.
- W2358988440 hasPublicationYear "2009" @default.
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