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- W2359005188 abstract "Objective:To investigate the effects of Shenfu injection on the expression of apoptosis-inducing factor(AIF) in the nucleus and AIF mRNA of cerebral cortex of in neonatal rats with hypoxic-ischemic brain damage(HIBD),in order to explore the mechanism of Shenfu injection inhibiting apoptosis.Methods:Seven-day-old Sprague-Dawley rats were randomly divided into three groups:sham operation group(S),control group(C),Shenfu injection treatment group(SF),They were further divided into six subgroups(n=8 per subgroup) according to the time points 3h,6h,12h,24h,3d,7d.Models of postnatal 7-day Sprague Dawley(SD) rats with HIBD were established with Rice method.In each subgroup,to detect the dynamic changes of AIF in nuclear,AIF mRNA expression and apoptosis cells.Results:(1) AIF translocation to nucleus began as early as 3h after HI,peaked at 24h,then gradually decreased after HI.The expression of AIF in group SF was lower than group C from 24h to 7d(P0.05).(2) AIF mRNA in group S had only very low expression;The expression of AIF mRNA in group C began increase 3h after HI insult,peaked 24 h after HI,then gradually decreased;AIF mRNA of group SF was markedly lower than that of group C at any time(P0.05).(3) The number of apoptotic cells of group C and group SF began to increase,peaked at 24h and then decreased after HI;the number of apoptotic cells of group SF at 24h,3d,7d were significantly lower than group C(P0.05).Conclusions:Shenfu injection can inhibit apoptosis by inhibiting AIF nuclear translocation and gene transcription,and thus play a protective role in HIBD." @default.
- W2359005188 created "2016-06-24" @default.
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- W2359005188 date "2013-01-01" @default.
- W2359005188 modified "2023-09-23" @default.
- W2359005188 title "Effect of Shenfu Injection on apoptosis induced cytokine expression of neonatal rats with hypoxic-ischemic brain injury" @default.
- W2359005188 hasPublicationYear "2013" @default.
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