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- W2359006222 abstract "Enterovirus 71(EV71) is a major causative agent of epidemics of hand-foot-mouth disease which associates with severe neurological disease,but the mechanism of EV71 pathogenesis remains unknown.In this study,we aimed to construct EV71 infected suckling mouse model and to evaluate immunological,endocrinological,and pathological characteristics of this model.In order to construct EV71 infected suckling mouse model,the clinical isolates of EV71 were purified by plaque purification,adapted to 3T3 cells,and then used infected suckling mice.EV71-BJ strain(GenBank accession NO.JQ319054) was finally achieved,which can make 7-day-old suckling mice infection and death.After the 7-day-old suckling mice were infected,we observed the clinical disease scores,body weight changes,and mortality.On 6 days post infection,viral loads of the brains and muscles,immune molecule levels,endocrine hormone levels,and pathological damages of the brains and muscles were determined by real-time RT-PCR,cytometric bead array(CBA),ELISA and histopathology,respectively.The virulence of EV71-BJ for 7-day-old suckling mice was 150 LD50/ml.The viral loads in muscles,with a peak on day 4 postinfection,were higher than that in brain.On 6 days post infection,more severe necrotizing myositis and infiltration of lymphocytes were observed in the mice muscles,with more significant rise of MCP-1,IFN-γ,IL-6 and TNF-α,compared with that of the mouse brains.However,no significant changes of epinephrine and cortisol were observed in the infected mice.In conclusion,an EV71 infected mouse model has been established,which will serve medicine screening,vaccines development and immunopathology researches for EV71 infection." @default.
- W2359006222 created "2016-06-24" @default.
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- W2359006222 date "2012-01-01" @default.
- W2359006222 modified "2023-09-26" @default.
- W2359006222 title "Immunological,endocrinological,and pathological characteristics of the EV71-BJ strain-infected suckling mice" @default.
- W2359006222 hasPublicationYear "2012" @default.
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