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- W2359013586 abstract "Objective In this experiment,we explored the effects of rAAV|hGDNF on protecting spinal neurons From death. Methods rAAV|hGDNF particals were produced by recombinant virus technolgy,and infected the culture spinal neurons which were exposed to glutamate.We counted the mortality rate and detected the expression of NOS mRNA by RT|PCR. Results In the group transfering rAAV|hGDNF the death rate was inhibited(50%±0^02,control 59^25%±0^023, P 0^05) and the expression of NOS mRAN was down regulated in the spinal neuronal cells(0^97±0^05),control 1^23±0^10, P 0^01).Conclusion The results suggested that the mechanisms of neuronal protection are related with inhibiting the free radicals production by rAAV|hGDNF." @default.
- W2359013586 created "2016-06-24" @default.
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- W2359013586 date "2002-01-01" @default.
- W2359013586 modified "2023-09-25" @default.
- W2359013586 title "THE EFFECT OF rAAV-hGDNF ON PROTECTING RAT SPINAL CORD NEURONS FROM DEATH INDUCED BY GLUTAMATE" @default.
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