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- W2359017039 abstract "Objective To investigate whether the mechanism of Shengmai injection on adriamycin-induced myocardium injury in rats is inhibiting the apoptosis.Methods The rat model of myocardium injury was made by injecting adriamycin into the pleural.The changes of heart rate were detected.The death rate was calculated.Cell apoptosis was detected by TUNEL.The measurements of CK-MB were detected.The expression level of Bax,Bcl-2 pertain and mRNA were detected by immunhistochemical method and RT-PCR.Results Shengmai Injection significantly increased the expression level of Bcl-2 protein and mRNA,while significantly reduced Bax protein.It reduced the serum CK-MB concentration,reduced the apoptosis index and the death rate(P0.01 or 0.05),but it was somewhat dose-dependent.Conclusion Shengmai injection can obviously decrease the adriamycin-induced myocardium injury in rats and protect myocardium,whose mechanism may be inhibiting the apoptosis." @default.
- W2359017039 created "2016-06-24" @default.
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- W2359017039 date "2008-01-01" @default.
- W2359017039 modified "2023-09-23" @default.
- W2359017039 title "Protective effect of Shengmai injection on adriamycin-induced myocardium injury in rats and its mechanism" @default.
- W2359017039 hasPublicationYear "2008" @default.
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