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- W2359021213 abstract "OBJECTIVE : To summarize the progress in study of cervical carcinoma associated stem cells.METHODS : Relative articles between Jan.2000to May.2012were searched in Medline and CNKI journal with Uterine cervical carcinoma,stem cells and stem cell signaling pathway as key words,and finally 31articles were collected.Inclusion criteria : stem cells in normal cervix;cancer stem cells and mesenchymal stem cells isolated from cervical carcinoma;stem cell signaling pathway associated with treatment resistance to chemotherapy and radiotherapy in cervical carcinoma.RESULTS : The reserved cells isolated from the basal layer in normal cervical tissue showed the capability of cervical stem cells.Cancer stem cells could be separated from cervical cancer cell lines and fresh tissue specimens.These cells showed clear molecular phenotype,such as aldehyde dehydrogenase,some studies suggested that side population cells represented cervical cancer stem cells,which were ABCG2 / BCRP1positive.Enriched as spheroids,cervical cancer stem cells expressed embryonic and adult stemness-related genes(Nanog,Oct-4and Sox-2) and were capable of generating reproducible tumor phenotypes in nude mice with enhanced tumorigenicity.Mesenchymal stem cells(MSCs) constitute a rare non-hematopoietic population which could be defined according to its ability to self-renew and differentiate into adipose,cartilage,and bone,but controversy exised regarding their presence and role in solid tumors.MSCs with normal karyotype and multipotential differentiation were identified and confirmed in cervical cancer tissues.Activation of genes of epithelial-mesenchymal transformation could induce cancer stem cell phenotype.Stem cells signaling pathways contributed to the occurrence,the progression and metastasis,even treatment resistance of cervical cancer,such as the Hedgehog pathway,TGFβ pathway.Modulation or inhibition corresponding pathway might inhibit tumor growth and reduce chemotherapy and radiation resistance.CONCLUSIONS : This article reviewed the progress of stem cells associated with cervical carcinoma,which provided the probability of radical curing cervical cancer by specific detection and targeting of stem cells and pathways associated with carcinoma." @default.
- W2359021213 created "2016-06-24" @default.
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- W2359021213 date "2013-01-01" @default.
- W2359021213 modified "2023-09-26" @default.
- W2359021213 title "Research progress of cervical carcinoma associated stem cells" @default.
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