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- W2359022626 abstract "OBJECTIVE:To study whether interferon-γ can enhance the specific CTL lysis of the tumor cells and its effect on the HLA-I molecules of the tumor cells. METHODS: The mRNA level of β2-microgloblin(β2-m) in the tumor cell were detected by RT-PCR. The expression of HLA-A2 on the tumor cells were detected by flow cytometry. Lymphocytes were primed by DCs, which were derived from cord blood and pulsed with whole tumor cell lysates. The susceptibility of the hepatocarcinoma cell to CTL lysis under the stimulation of interferon-γ were investigated by cytotoxicity test. RESULTS: The interferon-γ increased the mRNA level of β2-m and the expressions of HLA-A2 on the tumor cells. Forty hours after interferon-γ was added, the mRNA level of β2-m was significantly higher than that of 0 hour group (the relative light densities were 1.104±0.259 and 0.674±0.135, respectively, t=-2.992, P=0.040), and still kept high levels at 72 and 96 hours. The augment of HLA-A2 on the tumor cells were consistent with the mRNA level of β2-m. Vaccine of cord blood derived-DCs had an inhibitory activity on growth of human hepatocarcinoma cells, but no effect on Caski cells in vitro. The interferon-γ enhanced the specific CTL lysis of the tumor cells. CONCLUSION Interferon-γ can enhance the susceptibility of the tumor cell to CTL lysis, and the mechanism is associated with the enhanced mRNA level of β2-m in hepatocacinoma and the expression of classⅠHLA molecule on the tumor cell." @default.
- W2359022626 created "2016-06-24" @default.
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- W2359022626 date "2008-01-01" @default.
- W2359022626 modified "2023-09-24" @default.
- W2359022626 title "Study on the susceptibility of the hepatocarcinoma cell to DC-derived CTL lysis under the stimulation of interferon-γ" @default.
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